Hydration Blog

A genetic reason for why some people lose more salt in their sweat than others?

Wednesday, November 21, 2022

A genetic reason for why some people lose more salt in their sweat than others?

We recently came across an interesting study from the USA which offers a very good explanation of why some people are high salt sweaters and others low or normal.  This group in question biopsied the skin of 3 groups of people - those with cystic fibrosis (known to have high levels of sodium and chloride in their sweat), those with high sweat sodium levels but not CF sufferers and those with normal sweat sodium levels.  Those with CF and high salt sweaters had a lower abundance of a protein called cystic fibrosis transmembrane conductance regulator (CFTR).  This protein is responsible for absorption of chloride and sodium in the sweat gland so a lower level means less is absorbed back into the blood and more is excreted out in sweat.  


Ref:

Brown MB.  Low abundance of sweat duct Cl channel CFTR in both healthy and cystic fibrosis athletes with exceptionally salty sweat during exercise.  Am J Physiol Regul Integr Comp Physiol. 2011; 300: R605–R615

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